Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity's greatest challenges.About the Role:
We have an exciting opportunity for a Postdoctoral Fellow to join the Vento-Tormo Lab https://ventolab.org in our Cellular Genetics Programme for a 3 year contract.
You will be working on an exciting project funded by UKRI to study human placental development and the uterine microenvironment. You will use machine learning and bioinformatics tools to study the maternofoetal communication during early pregnancy. For this, you will use multimodal single-cell datasets of placental specimens and genetically perturbed in vitro placental models. With this comprehensive approach, we will gain insight into the effects that gene perturbations have on transcriptional effects and their role in gene regulatory networks in the setting of different placental cell populations and its communication with maternal uterine cells.Most relevant publications:
Arutyunyan et al Spatially resolved single-cell multiomics map of human trophoblast differentiation in early pregnancy Biorxiv 2022 Nature In Press https://www.biorxiv.org/content/10.1101/2022.11.06.515326v1
Garcia-Alonso et al Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro Nature Genetics 2021 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648563/
Vento-Tormo et al Single-cell reconstruction of the early maternal-fetal interface in humans Nature 2018 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7612850/You will be responsible for:
Your position will be in the Vento lab, where you will study human placental development and the uterine microenvironment. You will work closely with other groups on the project, including other computational members of Cellular Genetics. You will take the scientific lead on optimising the existing computational tools, but also establishing novel bioinformatics and machine learning tools to integrate multimodal single-cell datasets and study cell-cell communication. This project will involve close collaboration with an experimental postdoc to analyse and interpret the data.About You:
You have experience working with cell culture, large-scale genomic data generation and gene editing. You are independent, but comfortable working as a part of a bigger team. We welcome your application if you have skills and experience in the following:
Joining us as a Postdoctoral Fellow:
- Cell cultures and organoids, especially on a high throughput scale
- Gene editing (CRISPR/Cas9) and screening
- Cellular assays
- Single cell RNA sequencing
- Developmental biology
You will be part of a vibrant international Postdoctoral Fellow community at the Sanger Institute with a wide programme of transferable skills training and excellent career development opportunities. For more information about being a Postdoctoral Fellow - please visit: https://youtu.be/1-vxm2nBmFAEssential Skills:
- PhD in bioinformatics, mathematics, physics or related discipline
- Evidence of good productivity through publications
- Knowledge of statistics
- Knowledge of R or Python applied to image and data analysis.
- Excellent communication, organisational and presentation skills
- Excellent problem solving and troubleshooting skills
- Ability to work independently and organize own workload
- Ability to organize, plan and prioritize tasks or projects
- Demonstrate good networking, influencing and relationship building skills
- Ability to communicate ideas and results effectively
- Demonstrates inclusivity and respect for all
- Ability to build collaborative working relationships with internal and external stakeholders
Other Information:Salary per annum:
- Experience modelling cell-cell interactions
(dependent upon skills and experience): £35,707-£44,712 Application Process:
Please apply with your CV and a Cover Letter outlining how you meet the criteria set out above.Closing Date: 21st March 2023Working at Wellcome Sanger:
Our flexible-hybrid working environment is designed to support a healthy work-life balance. This means you can work flexibly with a combination of working from home, and working from our Campus to allow you to focus on being productive and part of the team while enjoying the benefits of working flexibly.
We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.
We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That's why we're committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.Our Benefits:
We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.